Tatarstan Airlines is flying from Perm to Prague (traveling time is 4 hours), however, departures are not carried out regularly, the exact schedule should be specified in advance. Another option is to fly over Ekaterinburg, where you can get from Perm by 1 hour by plane. From Ekaterinburg to Prague, flights are carried out on a regular basis (travel time is 4 h 40 min.)

In addition, you can fly through Moscow, from where much more flights depart to Prague (the flight from Perm to Moscow takes about 2 hours).