The fastest and most convenient way to get from Prague to Karlovy Vary is by bus (unless of course you are driving yourself by car) .Comfortable buses of the carrier Student Agency leave from the bus station Florenc, which is located at the same metro station, and follow to Karlovy Vary just over 2 hours .There will be one stop on the way - just at the airport .Vaclav Havel (former Ruzyne), then the bus will continue without interruption .Tickets are sold at the ticket office of the train station or at the bus driver .Buy tickets online and find out the flight schedule on the carrier's website .

Trains from the main railway station also leave for Karlovy Vary. But to go longer - 3, 5 hours.