There are no direct trains on this route, you will have to go with a transfer in Antwerp or Brussels. Docks, as a rule, pass easily and without adventures, the timetable of the drivers is observed exactly. The ticket is usually accompanied by a card showing the transfer time

The total travel time is 4 hours if traveling through Antwerp on IC trains and 3 hours if you combine IC with high-speed Thalys. Such a ticket will cost 48-75.40 EUR one way for the place in the 2nd class and 76-89 for the place in the 1st class

If you go through Brussels, the average and minimum prices will be the same. Trains IC and Thalys go the same 3 hours, but IC spend a little longer, 4 hours and 15 minutes. But the time of docking in Brussels usually turns out to be shorter, only about 12-15 minutes

Eurolines bus ride, of course, will take longer, it will take almost 5 hours. But it will be much cheaper, the ticket for an adult passenger (over 26 years old) will cost 30-33 EUR with all fees, and for some flights in general, 25 EUR. In addition, the buses go without a change. True, only once a day, in the morning. So, what kind of transport to choose is up to you.